The pain -- I thought church would be different -- The pain goes so deep -- Where does all this pain come from? -- Nobody sees me -- I feel beat up in church -- I live in shame all the time -- I feel used -- I can't forgive -- The hope -- Will I ever get past the pain? -- Why do I feel so unsafe in church? -- I can't keep up with all the rules -- What's (...) wrong with these people? -- I just need to be perfect -- The church doesn't seem to care -- How do I find a good church? -- Hope beyond the pain -- Demonic lies and doctrines -- Learning to live in the kingdom of light. (shrink)

Familial clustering of a disease is defined as the occurrence of the disease within some families in excess of what would be expected from the occurrence in the population. It has been demonstrated for several cancer types, ranging from rare cancers as the adenomatosis-coli-associated colon cancer or the Li-Fraumeni syndrome to more common cancers as breast cancer and colon cancer. Familial clustering, however, is merely an epidemiological pattern, and it does not tell whether genetic or environmental causes or both in (...) combination are responsible for the familial clustering. Familial clustering may be due to genetic predisposition to the disease, but exposure to environmental factors — shared by members of some families, but not by members of other families — may also cause familial clustering and hence mimic genetic inheritance in the study of nuclear families. Based on assumptions regarding the individual steps in the biological process starting with exposure to carcinogens and ending with death from disseminated cancer we suggest that genetic and environmental factors may both be involved in most of these steps. The present paper focuses on research methodologies necessary to discriminate between the effect of genes and family environment in the development of cancer. (shrink)

The European Clinical Trials Directive (EU 2001; 2001/20/EC) was introduced to improve the efficiency of commercial and academic clinical trials. Concerns have been raised by interested organizations and institutions regarding the potential for negative impact of the Directive on non-commercial European clinical research. Interested researchers within the European Group for Blood and Marrow Transplantation (EBMT) were surveyed to determine whether researcher experiences confirmed this view. Following a pilot study, an internet-based questionnaire was distributed to individuals in key research positions in (...) the European haemopoietic SCT community. Seventy-one usable questionnaires were returned from participants in different EU member states. The results indicate that the perceived impact of the European Clinical Trials Directive has been negative, at least in the research areas of interest to the EBMT. (shrink)

Marina Gustavovna Shtorkh is a daughter of Gustav Shpet (1879-1937), one of the most important Russian philosophers of the 20th century. He spent the last two years of his life (1935-1937) in exile in Siberia. M.G. Shtorkh shares her memories in a documentary film about her father and his circle, the intellectual leaders of the Silver Age, philosophers, actors, artists: A. Belyi, V. Kachalov, I. Moskvin, A. Shchusev, B. Pil`niak, etc. This book by Elena Iakovich is a transcript of the (...) film. (shrink)